1About CCBRRecommend/recommend-210true 00false10000-00-00 00:00:000000-00-00 00:00:00 1false118About CCBRCms/about-ccbr140trueAbout CCBR Clinical Research 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 14false168History of CCBRCms/about-ccbr/history-of-ccbr18600trueCCBR | History of CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 60false180Current StudiesCms/patients/current-studies22720trueCCBR - Current Studies 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 72false187Alzheimer´s DiseaseCms/participants/disease-areas/alzheimers-disease77790trueAlzheimer´s Disease - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 79false117HomeCms/41131trueCCBR Clinical Research 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 13false119ServicesCms/services151trueCCBR Services 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 15false165Executive ManagementCms/about-ccbr/executive-management18571trueCCBR Executive Management 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 57false170Phase IbCms/services/phase-Ib19621trueCCBR Research Phases 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 62false188High CholesterolCms/participants/disease-areas/high-cholesterol77801trueHigh Cholesterol - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 80false195Patient InformationCms/patients/patient-information22871trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 87false13NewsNewsExtended/news4112trueCCBR News 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.00false10000-00-00 00:00:000000-00-00 00:00:00 1false166Operationel ManagementCms/about-ccbr/operationel-management18582trueCCBR Operationel Management 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 58false171Phase II-IVCms/services/phase-ii-iv19632trueCCBR Research Phases 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 63false177Disease AreasCms/participants/disease-areas22692trueCCBR Disease Areas 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 69false189HypertensionCms/participants/disease-areas/hypertension77812trueHypertension - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 81false1124CCBR BlueprintCms/ccbr-blueprint1132trueCCBR Blueprint 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 113false115LinksCms/links41113trueCCBR Links 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 11false167FinanceCms/deleted/67-1593trueCCBR Finance Department 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 59false172Project ManagementCms/services/project-management19643trueCCBR Project Management 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 64false178Therapeutic AreasCms/therapeutic-areas703trueCCBR Therapeutic Areas 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 70false179Research ActivitiesCms/patients/research-activities22713trueCCBR Research Activities 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 71false190OsteoarthritisCms/participants/disease-areas/osteoarthritis77823trueOsteoarthritis - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 82false122PatientsCms/patients184trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 18false173Regulatory AffairsCms/deleted/73-1654trueCCBR Regulatory Affairs 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 65false181Why apply as a participant?Cms/patients/why-apply-as-a-participant22734trueCCBR Participant Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 73false191OstoeporosisCms/participants/disease-areas/ostoeporosis77834trueOstoeporosis - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 83false11040JobsCms/topmenu/jobs419244false 00false10000-00-00 00:00:000000-00-00 00:00:00 924false116ContactCms/contact41125trueCCBR Contact Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 12false138Research CentresUserObject/research-centres15trueCCBR Clinical Research Centres 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 1false182FAQCms/patients/faq22745trueCCBR - FAQ 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 74false192PainCms/participants/disease-areas/pain77845truePain - CCBR Clinical Research 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 84false141TopMenuMenu/topmenu6falseCCBR Clinical Research 0000false10000-00-00 00:00:000000-00-00 00:00:00 false193Respiratory DiseasesCms/participants/disease-areas/respiratory-diseases77856trueRespiratory Diseases - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 85false176Patient recruitment and retentionCms/services/Patient_recruitment_and_retention19687truePatient recruitment and retention 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 68false194Rheumatoid ArthritisCms/participants/disease-areas/rheumatoid-arthritis77867trueRheumatoid Arthritis - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 86false126StandardElementCms/standardelement-22210true 00false10000-00-00 00:00:000000-00-00 00:00:00 22false137Terms of useCms/Terms-of-use-23321true 00false10000-00-00 00:00:000000-00-00 00:00:00 33false139SimpleContactCms/simplecontact-23422true 0false10000-00-00 00:00:000000-00-00 00:00:00 34false148Thanks for contacting usCms/thanks-for-contacting-us-24136true 0false10000-00-00 00:00:000000-00-00 00:00:00 41false174Quality AssuranceCms/services/quality-assurance196662trueCCBR Quality Assurance 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 66false197What is a clinical trialCms/patients/patient-information/what-is-a-clinical-trial958974trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 89false198Why perform clinical trials?Cms/patients/patient-information/why-perform-clinical-trials959075trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 90false199Why do people choose to participate i clinical trials?Cms/patients/patient-information/why-do-people-choose-to-participate-i-clinical-trials959176trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 91false1100Who can participate in clinical trialsCms/patients/patient-information/who-can-participate-in-clinical-trials959277trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 92false1101What are the risks associated with clinical trials?Cms/patients/patient-information/what-are-the-risks-associated-with-clinical-trials959378trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 93false1102How can I get involved in clinical trials?Cms/patients/patient-information/how-can-i-get-involved-in-clinical-trials959479trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 94false1103What are my rights as a participant?Cms/patients/patient-information/what-are-my-rights-as-a-participant959580trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 95false1104What are my responsebilities?Cms/patients/patient-information/what-are-my-responsebilities959681trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 96false1105How am I protected?Cms/patients/patient-information/how-am-i-protected959782trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 97false1106Do I have to pay anything to participate in a clinical trial?Cms/patients/patient-information/do-i-have-to-pay-anything-to-participate-in-a-clinical-trial959883trueCCBR Patient Information 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 98false1196Kontakt kasseCms/kontakt-kasse-2184164true 0false10000-00-00 00:00:000000-00-00 00:00:00 184false1814Type 2 DiabetesCms/participants/disease-areas/type-2-diabetes77724765trueType 2 Diabetes - CCBR 0CCBR Clinical Research is the leading global provider of specialized outsourced clinical services.0false10000-00-00 00:00:000000-00-00 00:00:00 724false1816Memory ResearchCms/memory-research-2726767true 0false10000-00-00 00:00:000000-00-00 00:00:00 726false11044Cookie politics internationalCms/cookie-politics-international-2927989true 0false10000-00-00 00:00:000000-00-00 00:00:00 927false1
Disease Areas

Osteoarthritis
 

What is osteoarthritis?

Osteoarthritis is a type of arthritis that is caused by the breakdown of the cartilage in one or more joints in the body. Cartilage serves as a "shock absorber" between the bones in the joints. Another name for Osteoarthritis is “degenerative arthritis”. Osteoarthritis is by far the most common type of arthritis.

Osteoarthritis becomes more frequently as people age. Before the age of 45, osteoarthritis occurs more frequently in males than females and after the age of 55, it occurs more frequently in females. The progression of osteoarthritis is slow, occurring over several years or decades.

Osteoarthritis most commonly affects weight bearing joints e.g. hips and knees but can also affect the hands, feet, spine.
Most cases of osteoarthritis have no known cause, and these cases are referred to as Primary osteoarthritis, but when the cause of the osteoarthritis is known e.g. trauma, the condition is referred to as Secondary.
 
Pain is usually the initial symptom in osteoarthritis, with deep, achy joint pain exacerbated by extensive use. Also, reduced range of motion and crepitus are frequently present. Stiffness during rest may develop, with morning joint stiffness usually lasting for less than 30 minutes.
 
Initially, pain can be relieved by rest and may respond to simple analgesics. However, joints may become unstable as the osteoarthritis progresses; therefore, the pain may become more prominent (even during rest) and may not respond to medications.
 

What causes osteoarthritis?

Primary osteoarthritis is most of the time related to aging processes. Aging decreases the water content of the cartilage and the cartilage begins to degenerate. In progressed cases, there is a total loss of cartilage between the bones in the joints. Repetitive use of the worn joints can irritate and inflame the cartilage, causing pain and swellings. Loss of the cartilage results in increased friction between the bones in the joints. This leads to pain and limitation of joint mobility. Inflammation of the cartilage can also stimulate new bone growths such as spurs to form around the joints.

Secondary osteoarthritis is caused by conditions such as obesity, repeated trauma or surgery in the joint, abnormal joints at birth (congenital abnormalities), diabetes and other hormone disorders.

Obesity causes osteoarthritis by increasing the mechanical stress on the cartilage. Obesity, next to aging, is the biggest risk factor for osteoarthritis in the knees and hips. Repeated trauma to joint tissue (e.g. ligaments, bones, and cartilage) is believed to lead to early osteoarthritis in the knees.

Some people are born with abnormally formed joints (congenital abnormalities). These people are especially vulnerable to mechanical wear, causing early degeneration and loss of cartilage in the affected joint.

If you suffer from osteoarthritis and are interested to learn more about participating in a clinical trial, please fill out the form, and we will contact you with more information.